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首页> 外文OA文献 >Investigation of the environmental transport of human pharmaceuticals to surface water: a case study of persistence of pharmaceuticals in effluent of sewage treatment plants and hospitals in Malaysia
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Investigation of the environmental transport of human pharmaceuticals to surface water: a case study of persistence of pharmaceuticals in effluent of sewage treatment plants and hospitals in Malaysia

机译：人类药物向地表水的环境迁移研究：以马来西亚污水处理厂和医院废水中药物的持久性为例

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The present work reports the occurrence and monitoring of 11 pharmaceuticals (i.e., caffeine, prazosin, enalapril, carbamazepine, nifedipine, gliclazide, levonorgestrel, simvastatin, hydrochlorothiazide, diclofenac-Na and mefenamic acid) in surface water and in the influent and effluent of sewage treatment plants (STPs) and hospitals (HSPs). A total of 105 water samples were analyzed using solid-phase extraction combined with liquid chromatography-time-of-flight/ mass spectrometry (SPE-LC-TOF/MS). The mean concentrations of the detected pharmaceuticals in STP influent and effluent ranged from limit of quantification (LOQ) to 3909 ng L-1 and 12 to 577 ng L-1, respectively. The mean concentrations of the detected pharmaceuticals in the hospital influent and effluent ranged from 28 to 1644 ng L-1 and 20 to 1540 ng L-1, respectively. The highest concentration detected in the sampling points was 9099 ng L-1 for caffeine in influent STP. The presence of prazosin has never been reported before in literature. In this study, prazosin was detected in all studied samples, and the highest concentration was 525 ng L-1 in influent STP. Chemometric analysis was used to assess the presence of pharmaceuticals in samples.
机译：本工作报告了地表水以及污水的进水和出水中11种药物（即咖啡因，哌唑嗪，依那普利，卡马西平，硝苯地平，格列齐特，左炔诺孕酮，辛伐他汀，氢氯噻嗪，双氯芬酸钠和美芬那酸）的发生和监测。处理厂（STP）和医院（HSP）。使用固相萃取结合液相色谱-飞行时间/质谱分析（SPE-LC-TOF / MS）对总共105个水样品进行了分析。 STP进水和出水中检测到的药物的平均浓度分别为定量限（LOQ）至3909 ng L-1和12至577 ng L-1。医院进水和出水中检测到的药物的平均浓度分别为28到1644 ng L-1和20到1540 ng L-1。在进水STP中，咖啡因的采样点中检测到的最高浓度为9099 ng L-1。以前没有文献报道过哌唑嗪的存在。在这项研究中，在所有研究样品中均检出了哌唑嗪，进水STP中的最高浓度为525 ng L-1。化学计量分析用于评估样品中药物的存在。

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